Kedu ka mmanya na -egbu si eme ka mmadụ runkụbiga mmanya ókè?

Ndinaya

• Isi ihe
• Mmanya na -egbu egbu na -eme ka mmadụ na ụmụ oke viaụbiga mmanya ókè site na usoro ụbụrụ.
• Icheta ALDH2 nwere nkwa maka ịgwọ nsogbu mmanya.

Isi ihe

• Nchọpụta ọhụrụ na -egosi na ALDH2 enzymes na -arụ ọrụ dị mkpa n'otú ụbụrụ si emeghachi omume na nnukwu mmanya.
• Enzymes ALDH2 nwekwara ike jikọta ya na mmetụta omume na-adịkarị nke ị alcoholụ mmanya na-aba n'anya-dị ka ikwu okwu nzuzu, nhazi na-adịghị mma, wdg.
• Ịghọta njikọ a nke ọma nwere ike ibute ọgwụgwọ ka mma nke nsogbu mmanya.

Na mbido afọ a, ndị nyocha nọ na Finland bipụtara ọmụmụ (Kekkonen et al., 2021) na -egosi na ị drinkingụ mmanya siri ike ("binge") site n'oge uto ruo na nwata etolite na cerebellum gbanwere. Ugbu a, ọmụmụ ọzọ ebipụtara na nso nso a gbasara mmanya na ụbụrụ na -etinye cerebellum n'ihu na etiti.

Ọmụmụ ihe ọhụrụ (Jin, Cao, Yang, et al., 2021) n'ime ka ụbụrụ si eme ka mmanya na -aba n'anya na -atụ aro na enzymes ALDH2 astrocytic na cerebellum nwere ike rụọ ọrụ amatabeghị na mmanya na -egbu (ya bụ, mmịnye ethanol). E bipụtara nchoputa nyocha ndị ọgbọ a na Machị 22 n'akwụkwọ akụkọ mepere emepe Metabolism nke Nature .

"Anyị chọpụtara na egosipụtara ALDH2 na sel ndị a maara dị ka astrocytes na cerebellum, mpaghara ụbụrụ na-achịkwa nguzozi na ịhazi igwe," onye na-ede akwụkwọ Qi Cao nke Mahadum Maryland School of Medicine kwuru na mwepụta akụkọ Eprel 14. "Anyị chọpụtakwara na mgbe ewepụrụ ALDH2 na mkpụrụ ndụ ndị a, ụmụ oke ndị ahụ na -eguzogide nrụrụ ụgbọ ala nke mmanya na -aba n'anya kpatara."

Mmanya na -egbu egbu na -eme ka mmadụ na ụmụ oke viaụbiga mmanya ókè site na usoro ụbụrụ.

Site na inyocha anụ ahụ ụbụrụ mmadụ site na cortex ụbụrụ na ịhụ ndụ ( na vivo ) ụmụ oke, ndị nyocha ahụ "chọpụtara na egosipụtara ALDH2 na cerebellum na astrocytes n'ime mmadụ na ụmụ oke."

Ọ bụ ezie na a chọkwuru nyocha mmadụ, ọmụmụ a na ụmụ oke dị ndụ na -atụ aro na acetate nwere ike rụọ ọrụ elefuru anya na mbụ ka esi ejikọ metabolism nke mmanya na ụbụrụ mmadụ na mgbanwe mgbanwe akparamagwa na akparamagwa (dịka. , mfu nke igbochi).

Na ngalaba Mkparịta ụka akwụkwọ ha, ndị dere chịkọtara ihe nyocha a pụtara:

"Data anyị na-egosi na cerebellar astrocytic ALDH2 na-ahazi metabolism ethanol, njikọ GABA, na nkwarụ moto ethanol kpatara. Nke a kwekọrọ n'ọmụmụ ihe gara aga na-egosi na cerebellum bụ mpaghara ụbụrụ nwere oke acetate dị elu na-eso oriri ethanol n'ime mmadụ. atụwo aro na cerebellum bụ mpaghara ụbụrụ a kacha eleda anya dị oke mkpa maka nnukwu ọrụ ụbụrụ na ọrịa akwara ozi.

Icheta ALDH2 nwere nkwa maka ịgwọ nsogbu mmanya.

Nchoputa ohuru (2021) nke Jin, Cao, Yang, et al. na -atụ aro na ọghọm nke etu cerebellum na mpaghara ụbụrụ ndị ọzọ si metabolize ethanol nwere ike jikọta ya na mmetụta na -emerụ ahụ nke ị alcoholụbiga mmanya ókè na ị drinkingụbiga mmanya ókè. Tụkwasị na nke a, nyocha a na -agbagha agbagha na -egosi na acetate emepụtara na ụbụrụ ya na acetate emepụtara na imeju nwere ike imetụta ọrụ moto na ọgụgụ isi n'ụzọ dị iche.

Ịkọwapụta ka mmanya na -emetụta cerebellum nwere ike ibute ọgwụgwọ ọrịa mmanya ọhụrụ (AUD). "Nchọpụta [anyị] na -atụ aro na ALDH2 astrocytic bụ ebumnuche dị mkpa nke na -agbagha metabolism na ime mmanya na ụbụrụ," ndị dere kwuru. "Data anyị na-egosi na ALDH2 astrocytic bụ ihe dị mkpa, mana amabeghị ya, ebumnuche na ụbụrụ iji gbanwee ọgwụ na-aba n'anya ma nwee ike ịgwọ ọrịa mmanya."

Cao kwubiri, "Ihe ọzọ anyị ga -eme bụ ịchọpụta ma usoro ndị a a na -ahụ n'ime oke na -adịkwa n'ime mmadụ." "Anyị ga -achọ ịma ma a na -ahazi metabolism nke mmanya n'ime ụbụrụ mmadụ. Ọ bụrụ na nyocha ọzọ gosikwara na nke a bụ ikpe, ọ nwere ike ibute ebumnuche ọhụrụ maka ịgwọ ọrịa mmanya."

Foto Facebook: Dean Drobot/Shutterstock

Virve Kekkonen, Elisa Kallioniemi, Outi Kaarre, Mervi Könönen, Petri Kivimäki, Heidi Gröhn, Tommi Tolmunen, Ritva Vanninen. Mmanya (Nke mbụ dị na ntanetị: February 06, 2021) DOI: 10.1016/j.alcohol.2021.02.002